莫德纳交货延迟南韩拟率团赴美催货 蔡政府只会干等? 少康战情室 20210811
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xu azzl说:
Comparing the COVID-19 Vaccines: How Are They Different?
BY KATHY KATELLA AUGUST 10, 20212021-08-12 22:59:45 回复
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xu azzl说:
Pfizer-BioNTech
On December 11, 2020, this became the first COVID-19 vaccine to receive a Food and Drug Administration (FDA) Emergency Use Authorization (EUA), after the company reported positive initial clinical trial data that showed the vaccine was highly effective at preventing symptomatic disease. This is a messenger RNA (mRNA) vaccine, which uses a relatively new technology. It must be stored in freezer-level temperatures, which can make it more difficult to distribute than some other vaccines.
Pfizer also is the first company to submit a request to the FDA for full approval of its vaccine. In addition, it is seeking FDA authorization for a third dose, or booster dose, of its original vaccine, and says it is planning to start clinical trials in August to test a booster shot against the Delta variant.
Status: Emergency use in the U.S. and other countries, including in the European Union (under the name Comirnaty).
Recommended for: Anyone 12 or older. The vaccine is being studied in children ages 5-11.
Dosage: Two shots, 21 days apart; fully effective two weeks after second shot.
Common side effects: Chills, headache, pain, tiredness, and/or redness and swelling at the injection site, all of which generally resolve within a day or two of rest, hydration, and medications like acetaminophen. (If symptoms don’t resolve within 72 hours or if you have respiratory symptoms, such as cough or shortness of breath, call your doctor.) On rare occasions, the vaccine has appeared to trigger anaphylaxis, a severe reaction that is treatable with epinephrine (the drug in Epipens®). For that reason, the Centers for Disease Control and Prevention (CDC) requires vaccination sites to monitor everyone for 15 minutes after their COVID-19 shot and for 30 minutes if they have a history of severe allergies.
FDA Warnings: The FDA placed a warning label on the Pfizer vaccine regarding a “likely association” with reported cases of heart inflammation in young adults. This inflammation may occur in the heart muscle (myocarditis) or in the outer lining of the heart (pericarditis), and is considered important but uncommon—arising in about 12.6 cases per million second doses administered. The inflammation, in most cases, gets better on its own without medical intervention.
How it works: Unlike vaccines that put a weakened or inactivated disease germ into the body, the Pfizer mRNA vaccine delivers a tiny piece of genetic code from the SARS CoV-2 virus to host cells in the body, essentially giving those cells instructions, or blueprints, for making copies of spike proteins (the spikes you see sticking out of the coronavirus in pictures online and on TV). The spikes do the work of penetrating and infecting host cells. These proteins stimulate an immune response, producing antibodies and developing memory cells that will recognize and respond if the body is infected with the actual virus.
How well it works: Experts continue to learn about Pfizer’s efficacy both in the laboratory and in the real world. Pfizer’s initial Phase 3 clinical data presented in December showed its vaccine to have 95% efficacy. In April, the company announced the vaccine had 91.3% efficacy against COVID-19, based on measuring how well it prevented symptomatic COVID-19 infection seven days through up to six months after the second dose. It also found it to be 100% effective in preventing severe disease as defined by the CDC, and 95.3% effective in preventing severe disease as defined by the FDA. Another study, not yet peer-reviewed, provided more new data that brought the efficacy number down to 84% after 6 months, although efficacy against severe disease was 97%.
How well it works on virus mutations : A number of studies have focused on the vaccine and the mutations. In early May, the Pfizer vaccine was found to be more than 95% effective against severe disease or death from the Alpha variant (first detected in the United Kingdom) and the Beta variant (first identified in South Africa) in two studies based on real-world vaccinations. As far as the Delta variant (first seen in India), two studies reported by Public Health England that have not yet been peer reviewed showed that full vaccination after two doses is 88% effective against symptomatic disease and 96% effective against hospitalization. But Israel later reported the vaccine’s effectiveness in to be 90% effective against severe disease, and as low as 39% in its population in late June and early July. This could suggest that it is less effective against Delta or possibly waning over time, which has added to a debate about whether booster shots may be needed and for whom. All of this is still being monitored.
Moderna
Moderna’s vaccine was authorized for emergency use in the U.S. about a week after the Pfizer vaccine. Moderna uses the same mRNA technology as Pfizer and has a similarly high efficacy at preventing symptomatic disease. It also needs to be stored in freezer-level temperatures.
Status: Emergency use in the U.S and other countries, including in the European Union (it’s been approved in Switzerland) and other countries.
Recommended for: Adults 18 and older. While the vaccine is not yet available for children, the company says its vaccine provides strong protection for children as young as 12, and it is testing its efficacy for children ages 5-11.
Dosage: Two shots, 28 days apart, fully effective two weeks after the second dose.
Common side effects: Similar to Pfizer, side effects can include chills, headache, pain, tiredness, and/or redness and swelling at the injection site, all of which generally resolve within a day or two. On rare occasions, mRNA vaccines have appeared to trigger anaphylaxis, a severe reaction that is treatable with epinephrine (the drug in Epipens®). For that reason, the CDC requires vaccination sites to monitor everyone for 15 minutes after their COVID-19 shot, and for 30 minutes if they have a history of severe allergies.
FDA warnings: The FDA placed a warning label on the Moderna vaccine regarding a “likely association” with reported cases of heart inflammation in young adults. This inflammation may occur in the heart muscle (myocarditis) or in the outer lining of the heart (pericarditis), and is considered important but uncommon—arising in about 12.6 cases per million second doses administered. The inflammation, in most cases, gets better on its own without treatment.
How it works: Similar to the Pfizer vaccine, this is an mRNA vaccine that sends the body’s cells instructions for making a spike protein that will train the immune system to recognize it. The immune system will then attack the spike protein the next time it sees one (attached to a real SARS CoV-2 virus).
How well it works: Greater than 90% efficacy against cases of COVID-19 and more than 95% against severe cases, with approximately 6 months median follow-up after the second dose, according to the company. Earlier Phase 3 studies showed Moderna to be 94.1% effective at preventing symptomatic infection in people with no evidence of previous COVID-19 infection (although the efficacy rate drops to 86.4% for people ages 65 and older). In late March, a small CDC study that enrolled 3,950 health care personnel, first responders, and other essential and frontline workers showed the vaccine to be 90% effective upon full immunization (at least 14 days after the second dose) in real-world conditions.
How well it works on virus mutations: Some research has suggested that Moderna’s vaccine may provide protection against the Alpha and Beta variants. In June, Moderna reported that studies showed its vaccine is effective against the Beta, Delta, Eta, and Kappa variants, although it did show it to be about two times weaker against Delta than against the original virus. While more research is needed on Moderna’s efficacy against Delta, some experts believe it may work similarly to Pfizer since both are mRNA vaccines. All of this is still being monitored.2021-08-12 21:12:43 回复
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拼人品不確診说:
民进党梁议员说南韩去美国莫德纳抗议的是在野党人士,所以国民党也应该组团去抗议。
反正在台湾就是政府官员只领薪水,其他事就别人做,没做好与官员无关。
有政府请安心,但不放心~~。2021-08-12 22:13:44 回复











